Off-Label Antipsychotic Use Often Costly, Dangerous and Ineffective, Studies say

Many doctors prescribe antipsychotics for off-label uses, even when there’s little evidence that they’re effective, according to an article published Wednesday in the Journal of the American Medical Association. Also, physicians often don’t take precautions to mitigate the risks associated with these drugs, the article said.

Antipsychotics are used to treat a variety of health conditions, including major depression, Alzheimer’s disease and post-traumatic stress disorder. The Food and Drug Administration has not approved antipsychotic drugs for many of these conditions. Some researchers have questioned whether the cost and risk of some antipsychotic drugs warrant their off-label use.

Several major pharmaceutical companies have cumulatively paid billions of dollars in criminal fines and civil settlements for promoting unapproved uses of drugs, although the JAMA article does not mention this marketing as a potential cause of widespread off-label prescribing of antipsychotics. Antipsychotics are the top-selling drugs in the U.S., with $14.6 billion in sales in 2008, according to the article.

Related:
AstraZeneca Settles Off-Label Marketing Case for $520 Million
Johnson & Johnson Pushed Drug for Elderly After FDA Warning
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